Papers SASC
Metabolomics- and methylomics-based predictors for estimating health and biological aging
Daniele Bizzarri | 11-09-2024 | Metabolomics- and methylomics-based predictors for estimating health and biological aging Over the past decade, the abundance of high-throughput omics approaches coupled with the use of machine learning techniques, has made it possible to investigate the full molecular complexity of [...]
Depressive symptoms and plasma markers of Alzheimer’s disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies
Depressive symptoms and plasma markers of Alzheimer's disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies The Netherlands Consortium of Dementia Cohorts has performed a meta-analysis with 8 cohort studies to investigate the associations between depressive symptoms later in life and [...]
Healthful plant-based diet associates with greater well-being in older adults
A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact [...]
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function [...]
Osteoprotegerin: a double-edged sword in osteoarthritis development
Alejandro Rodríguez Ruiz | 22-10-2022 | Osteoprotegerin: a double-edged sword in osteoarthritis development To advance development of effective disease modifying OA treatments, a better understanding of its pathophysiological mechanisms is necessary. By studyinga family with early onset OA and high cartilage mineralization, a likely [...]
Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis
Evelyn Houtman | 22-10-2022 | Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis This thesis aims to increase the understanding of human osteoarthritis pathophysiology by developing reliable biomimetic ex vivo human osteochondral explant models and focussing on the [...]