Papers SASC
Genetic determinants of eating disorders
Rita Slof-Op 't Landt| 04-12-2007 | Genetic determinants of eating disorders In this thesis, a series of studies on different aspects of the genetics of eating disorders is presented. The heritability of disordered eating behavior and attitudes in relation with body mass index (BMI) [...]
Glycomics based biomarkers of the rate of aging: Development and applications of high throughput N-glycan analysis
Renée Ruhaak | 24-03-2011 | Glycomics based biomarkers of the rate of aging: Development and applications of high throughput N-glycan analysis Markers for longevity, which reflect the health condition and predict healthspan are extremely scarce. Such markers are, however, valuable in aging research. Protein [...]
Genes and Mediators of Inflammation and Development in Osteoarthritis
Steffan Bos | 15-09-2010 | Genes and Mediators of Inflammation and Development in Osteoarthritis Osteoarthritis (OA) mainly affects the articular cartilage covering the bones. In this thesis we investigated the relation between levels of inflammatory mediators, genes involved in their regulation and the disease [...]
Genetic Determinants of Healthy Longevity
Simon Mooijaart| 04-12-2007 | Genetic Determinants of Healthy Longevity Lifespan in under genetic control. In this thesis we translated genes regulating lifespan in model organisms to humans. First we identified DAF-12 as a critical gene for lifespan regulation in the nematode worm C. elegans. [...]
A Study into Genes Encoding Longevity in Humans
Maris Kuningas | 04-12-2007 |A Study into Genes Encoding Longevity in Humans The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the wide variability in lifespan between and within species. In [...]
Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease
Josine Min | 17-01-2007| Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease Osteoarthritis (OA) is a prevalent and complex disorder with a high hereditary probability. Previous genetic research into OA has yielded several common gene variants contributing to joint specific OA phenotypes. Only a few [...]