Publicaties Bio-Informatica
Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease
Josine Min | 17-01-2007| Generalised Osteoarthritis: from Mendelian Disorder to Complex Disease Osteoarthritis (OA) is a prevalent and complex disorder with a high hereditary probability. Previous genetic research into OA has yielded several common gene variants contributing to joint specific OA phenotypes. [...]
Familial osteorarthritis : risk factors and determinants of outcome
Naghmeh Riyazi | 22-11-2006 | Familial osteorarthritis : risk factors and determinants of outcome Osteoarthritis (OA) refers to a heterogeneous group of conditions. This thesis focuses on OA with a hereditary background; Familial OA at multiple joint sites and radiological hand [...]
Osteoarthritis and hemochromatosis, a genetic epidemiological study
B.Z. Alizadeh (Behrooz)| 23-03-2005 | Osteoarthritis and hemochromatosis, a genetic epidemiological study Osteoarthritis (OA) refers to a heterogeneous group of distinct diseases which express a common radiographic and clinical phenotype at diarthrodial joints.It is the leading cause of pain and [...]
Prestigieuze ZonMw Open Competitie beurs toegekend aan het LUMC, VU en RIVM
Prestigieuze ZonMw Open Competitie beurs toegekend aan het LUMC, VU en RIVM Onze levensverwachting stijgt wereldwijd, maar de jaren die we in goede gezondheid doorbrengen blijven achter. Mensen uit langlevende families bereiken vaak uitzonderlijk hoge leeftijden zonder dat ziektes [...]
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Proc Natl Acad Sci USA | November 2009 Abstract Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation [...]
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
Epigenetics & Chromatin | Volume 6 | article numebr 26 | 06 August 2013 Abstract DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due [...]