Maarten Rozing| 21-09-2011 | Endocrine and metabolic features of familial longevity The Leiden Longevity Study This thesis discusses the metabolic and endocrine characteristics of long-lived Dutch families. We found that familial longevity is marked by low thyroid function and preserved insulin [...]

Rita Slof-Op 't Landt| 04-12-2007 | Genetic determinants of eating disorders In this thesis, a series of studies on different aspects of the genetics of eating disorders is presented. The heritability of disordered eating behavior and attitudes in relation with body [...]

Renée Ruhaak | 24-03-2011 | Glycomics based biomarkers of the rate of aging: Development and applications of high throughput N-glycan analysis Markers for longevity, which reflect the health condition and predict healthspan are extremely scarce. Such markers are, however, valuable in [...]

Simon Mooijaart| 04-12-2007 | Genetic Determinants of Healthy Longevity Lifespan in under genetic control. In this thesis we translated genes regulating lifespan in model organisms to humans. First we identified DAF-12 as a critical gene for lifespan regulation in the nematode [...]

Maris Kuningas | 04-12-2007 |A Study into Genes Encoding Longevity in Humans The lifespan of an organism is determined by a complex network of environmental-, genetic- and stochastic factors. Each of these components contributes to the wide variability in lifespan between and [...]