Publicaties Bio-Informatica
Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA
Yolande Ramos | 26-05-2015 | Osteoarthritis, a degenerative disease of the articular joints : towards the implementation of functional genomics in OA Osteoarthritis (OA) is an age related disorder of the joints characterized by pain, crepitus, and stiffness resulting in decreased [...]
(Epi) genetics and twins
Jenny van Dongen | 16-04-2015 | (Epi)genetics and twins The research described in this thesis was characterized by two major themes: the first was related to the question to which extent variation between individuals in inflammation biomarkers and metabolic syndrome traits [...]
Computational Biology in Human Aging. An omics data integration approach
Erik van den Akker | 28-02-2015 | Computational Biology in Human Aging. An omics data integration approach Throughout this thesis, human aging and its relation to health are studied in the context of two parallel though complementary lines of research: biomarkers [...]
Studies into epigenetic variation and its contribution to cardiovascular disease
Rudolf Talens | 08-01-2015 |Studies into epigenetic variation and its contribution to cardiovascular disease Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks are faithfully transmitted during mitosis and are generally stable [...]
Genetic and biomarker studies of human longevity
Joris Deelen |25-06-2014 | Genetic and biomarker studies of human longevity The aim of this thesis was to identify novel lifespan regulating loci that influence human longevity and population mortality. To this end, we performed two genome-wide association studies, one of [...]
Transcriptomic studies in human ageing and longevity
Willemijn Passtoors | 19-12-2013 | Transcriptomic studies in human ageing and longevity The aim of this thesis was to identify in the human blood transcriptome, relevant pathways and potential biomarker profiles that associate with chronological age and discriminate between __healthy agers__ [...]