Papers Bio-Informatics
The role of TNFRSF11B in development of osteoarthritic cartilage.
The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford) | 2022 Feb 2;61(2):856-864. | doi: 10.1093/rheumatology/keab440 Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. Abstract Objectives: OA is a [...]
Publications 2022
PUBLICATIONS 2022 NOVEMBER OKTOBER SEPTEMBER AUGUSTUS JULI JUNI MEI APRIL MAART FEBRUARI JANUARI 2021 2020 2019 2018 QUESTIONS ABOUT OUR RESEARCH? ASK YOUR [...]
Leiden master’s student cracks epigenetic clock that predicts age – newsitem LUMC 14-01-2022
Researchers can accurately determine how old a person is based on the calibration of the DNA. To do this, they use a so-called epigenetic clock. Master's student Thomas Jonkman has now, nine years after the discovery, unravelled how this clock exactly [...]
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II I| November 5 - 2021 | Science Advances Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, Marga Bouma, H. Eka D. Suchiman, Roman i. Koning, Carolina r. Jost, [...]
Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis GalleryAccepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
Accepted manuscript: Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis | November 3 2021 | Rheumatology - https://doi.org/10.1093/rheumatology/keab826 Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, H Eka D Suchiman, Nico Lakenberg, Demiën Broekhuis, Rob G H H Nelissen, Yolande F M Ramos, Hailiang Mei, Davy Cats, Rodrigo [...]
Fibronectin binding to collagen type II is crucial for articular chondrocytes so stay in a healthy steady state
Marcella's latest publication in Science Advances is out now! Science Advances published the work of Marcella van Hoolwerff et al, where a high impact mutation was identified by exome sequencing in FN1 in affected family members of an early-onset osteoarthritis family. [...]