A long and healthy life is not for everyone. Why is one person worn out at the age of sixty while another can still cycle at the age of ninety? The Molecular Epidemiology department of the LUMC conducts research into the origin of these differences and how these differences can be reduced.

What affects the aging rate? Which mechanisms play a role in this? To investigate this, the researchers are looking at factors that cause people to age healthily. To this end, research is being conducted in long-lived families. In these families the majority manage to reach the age of ninety. What is their secret? Which genes are beneficial? What makes their bodies different from other people? Within this context, we focus on a healthy metabolism, disease and osteoarthritis.


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Molecular Epidemiology combines expertise in molecular epidemiology and computer science. This expertise is used for research, education and advice in order to contribute to the improvement of healthcare.

The mission of the research conducted within Molecular Epidemiology (MolEpi) is to monitor and understand factors that influence the risk of age-related disease(s) – aging – or the inverse factors involved in healthy aging. To this end, we generate and analyze state-of-the-art molecular data in human populations, families and groups of patients. In addition, in this context we focus on metabolic health and the relationship to cardiovascular disease. The research is anchored in themes and is carried out in three related research areas and the associated study populations: Aging osteoarthritis and epigenetic epidemiological research. The populations involved in these studies are also linked in biobanks within the BBMRI community.

For information about advice and cooperation with the Molecular Epidemiology section, please refer to this page.











Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations |September 2021 |Cell Cindy G Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida,........., Rob R G H H Nelissen, Margo Tuerlings, arcOGEN Consortium,.................., Ingrid Meulenbelt  , Ming Ta Michael Lee, Joyce B J van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini Abstract Osteoarthritis affects [...]

September 21st, 2021|News, Papers artrose|

How does hip osteoarthritis differ from knee osteoarthritis?

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. | Osteoarthritis Cartilage |  2021 [...]

September 19th, 2021|News, Papers artrose|

De eerste 1.000 dagen beïnvloeden het hele leven – NRC augustus 2021

NRC | 20 augustus 2021 | auteur Niki Korteweg Gezonde kinderen Een slechte start in de eerste duizend dagen na de conceptie zet een kind een leven lang op achterstand. Veel risicofactoren gaan samen: roken, drinken, stress… „Maar jonge kinderen hebben een enorme [...]

August 25th, 2021|News|

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants | 16-08-2021 | BMC Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, [...]

August 15th, 2021|News, Papers artrose|

Nature Reviews Cardiology publication about T cells in atherosclerosis

Nature Reviews Cardiology publiceerde een artikel over het effect van vetzuren op T cellen en de implicaties voor atherosclerose onder leiding van LUMC-onderzoekers Wouter Jukema (Cardiologie) en Bas Heijmans (Biomedische Datawetenschappen). ‘Het is hoog tijd voor meer aandacht voor T cellen in cardiovasculair [...]

July 20th, 2021|News, review|
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