The role of TNFRSF11B in development of osteoarthritic cartilage | May 2021 | Rheumatology (Oxford) Alejandro Rodríguez Ruiz, Margo Tuerlings, Ankita Das, Rodrigo Coutinho de Almeida, H Eka Suchiman, Rob G H H Nelissen, Yolande F M Ramos, Ingrid Meulenbelt Abstract Objectives Osteoarthritis (OA) is a complex genetic disease with different risk factors contributing to its development. One of the genes, TNFRSF11B, previously [...]
Censoring exosomal crosstalk in osteoarthritis |April 15 2021 | Nature Aging Ingrid Meulenbelt, Yolande F. M. Ramos, S. Rubina Baglio & D. Michiel Pegtel Abstract Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor [...]
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis | 20-02-2021 | Rheumatology and Therapy Evelyn Houtman, Marcella van Hoolwerff, Nico Lakenberg, Eka H. D. Suchiman, Enrike van der Linden-van der Zwaag, Rob G. H. H. Nelissen, Yolande F. M. Ramos & Ingrid Meulenbelt Introduction Likely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) [...]
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies | January 26 2021 | Addiction Biology Melissa A Munn-Chernoff, Emma C Johnson, Yi-Ling Chou, Jonathan R I Coleman, Laura M Thornton, ..................(including Meulenbelt I) Neale BM, Gerome Breen, Joel Gelernter, Howard J Edenberg, Cynthia M Bulik, Arpana Agrawal Abstract Eating disorders and substance use disorders frequently co-occur. [...]
Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis | January 2021 | European Journal of Endocrinology I C M Pelsma , K M J A Claessen, P E Slagboom, D van Heemst, A M Pereira, H M Kroon, Y F M Ramos, M Kloppenburg, N R Biermasz, and I M Meulenbelt Abstract Introduction Pathologically high growth hormone [...]
