Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian | 12-11-2020 | Leukemia
Erik B. van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H. Brugman, Tatjana Nikolic, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E. Jakobs, Daphne de Jong, P. Eline Slagboom, Frank J. T. Staal, Marcel J. T. Reinders & Henne Holstege
Age-related Clonal hematopoiesis (ARCH) is an inevitable consequence of ageing, which arises when an ageing hematopoietic stem cell (HSC) acquires a somatic mutation that confers a competitive growth advantage, leading to its gradual expansion . ARCH-associated mutations typically target genes associated with acute myeloid leukemia, most frequently the epigenetic regulators DNMT3A and TET2 . When a substantial proportion of the blood cells carries such a pre-leukemic mutation in an otherwise normal immuno-hematopoietic system, this state is also referred to as Clonal Hematopoiesis of Indeterminate Potential .
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