Publicaties Bio-Informatica
New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome [...]
Application of 3D human in vitro osteoarthritic chondrocyte models to study CCN4/WISP1 and Wnt signaling
Ritchie Timmermans | 07-11-2023 | Application of 3D human in vitro osteoarthritic chondrocyte models to study CCN4/WISP1 and Wnt signaling This thesis explores the role of CCN4/WISP1 and Wnt signaling in osteoarthritis (OA) using advanced 3D human in vitro chondrocyte models. [...]
The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy
Margo Tuerlings | 27-09-2023 | The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy Osteoarthritis (OA) is a prevalent age-related joint disease, determined by diverse changes in pathways maintaining articular cartilage and subchondral bone. This thesis aimed to [...]
A word of caution on the regression to the mean phenomenon in (biological) age prediction
A word of caution on the regression to the mean phenomenon in (biological) age prediction When predicting ‘biological age’, always consider whether regression to the mean could be an issue before drawing conclusions. Marije Sluiskes, Jelle Goeman, Marian Beekman, [...]
Osteoprotegerin: a double-edged sword in osteoarthritis development
Alejandro Rodríguez Ruiz | 22-10-2022 | Osteoprotegerin: a double-edged sword in osteoarthritis development To advance development of effective disease modifying OA treatments, a better understanding of its pathophysiological mechanisms is necessary. By studyinga family with early onset OA and high cartilage [...]
Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis
Evelyn Houtman | 22-10-2022 | Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis This thesis aims to increase the understanding of human osteoarthritis pathophysiology by developing reliable biomimetic ex vivo human osteochondral explant models and [...]