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New publication shows blood biomarkers for senescence endotypes in osteoarthritis patients
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function as biomarkers for patient-tailored targeting of senescence in OA. Accumulation [...]
A word of caution on the regression to the mean phenomenon in (biological) age prediction
A word of caution on the regression to the mean phenomenon in (biological) age prediction When predicting ‘biological age’, always consider whether regression to the mean could be an issue before drawing conclusions. Marije Sluiskes, Jelle Goeman, Marian Beekman, Eline Slagboom, Hein Putter and Mar Rodríguez-Girondo posted a PubPeer comment (a postpublication [...]