Papers
Computational Biology in Human Aging. An omics data integration approach
Erik van den Akker | 28-02-2015 | Computational Biology in Human Aging. An omics data integration approach Throughout this thesis, human aging and its relation to health are studied in the context [...]
Studies into epigenetic variation and its contribution to cardiovascular disease
Rudolf Talens | 08-01-2015 |Studies into epigenetic variation and its contribution to cardiovascular disease Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks [...]
Genetic and biomarker studies of human longevity
Joris Deelen |25-06-2014 | Genetic and biomarker studies of human longevity The aim of this thesis was to identify novel lifespan regulating loci that influence human longevity and population mortality. To this [...]
Transcriptomic studies in human ageing and longevity
Willemijn Passtoors | 19-12-2013 | Transcriptomic studies in human ageing and longevity The aim of this thesis was to identify in the human blood transcriptome, relevant pathways and potential biomarker profiles that [...]
Epigenetic differences after prenatal adversity: The Dutch Hunger Winter
Elmar Tobi | 29-10-2013 | Epigenetic differences after prenatal adversity: The Dutch Hunger Winter This thesis is a study on the link between early development and adult health. Studies in animal models [...]
Endocrine and metabolic features of familial longevity The Leiden Longevity Study
Maarten Rozing| 21-09-2011 | Endocrine and metabolic features of familial longevity The Leiden Longevity Study This thesis discusses the metabolic and endocrine characteristics of long-lived Dutch families. We found that familial longevity [...]