M Tuerlings, YFM Ramos, HED Suchiman, S Sayedipour, SD Joustra, A Rabelink-Hoogenstraaten, HA van Duyvenvoorde, DRJ Kempink, PB de Witte, I Meulenbelt, C de Bruin | 25-08-2026 | The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study. ABSTRACT Background Viable pediatric human growth plate (GP) tissue is rarely [...]
Rick Mulders, Mathew Nickel-Maunu,[...], and Ingrid Meulenbelt | 22-04-2026 | Human induced pluripotent stem cells (hiPSCs) offer a powerful platform to model chondrogenesis and enable regenerative strategies, yet regulation of cell-fate commitment remains elusive. Here, we systematically mapped cell-fate trajectories from 7 time points during a 49-day chondrogenic hiPSC differentiation protocol using single-nucleus multimodal [...]
Nickel Maunu M, Meulenbelt I, Ramos YFM | 22-07-2026 | Stem cells are key for development of disease modeling and therapies. While promising, however, current application of cutting-edge hiPSC technologies is, among others, confounded by cellular heterogeneity leading to concerns about their suitability for experimental and clinical applications. Variations across donors, tissue sources, methodologies, [...]
Giorgia Mazzini, Margo Tuerlings,[...], and Ingrid Meulenbelt | 08-06-2026 | Cell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ECM production by hiPSC-derived chondroprogenitors (hiCPCs), their derived chondrocytes (hiCHOs), and primary articular chondrocytes (hACs) [...]
Translational genomics of osteoarthritis in 1,962,069 individuals| May 2025 | Nature 641, pages1217–1224 K Hatzikotoulas, L Southam, L Stefansdottir, CG Boer, M-L McDonald, JP Pett, Y-C Park, M Tuerlings, R Mulders, … K Stefansson, I Meulenbelt, SA Teichmann, JBJ van Meurs, U Styrkarsdottir, E Zeggini. Abstract. Osteoarthritis is the third most rapidly growing health [...]
G Hajmousa, R Coutinho de Almeida, N Bloks, AR Rodríguez Ruiz , M Bouma, R Slieker, TB Kuipers, RGHH Nelissen, K Ito, C Freund, YFM Ramos, I Meulenbelt | 15-10-2024 | Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in OA. Abstract Background Lack of insight into factors that [...]
A damaging COL6A3 variant alters the MIR31HG-regulated response of chondrocytes in neocartilage organoids to hyperphysiologic mechanical loading | January 2024 | Advanced Science NG Bloks, Z Harissa, G Mazzini, SS Adkar, AR Dicks, G Hajmousa, N Steward, RI Koning, A Mulder, BBR de Koning, M Kloppenburg, R Coutinho de Almeida, YFM Ramos, F Guilak, [...]
When cells reach a permanent growth arrest (Senescence) and resist death, this can result in numerous diseases, such as osteoarthritis. Here we show the presence of two different types of senescence in the blood metabolome of osteoarthritis patients. These blood metabolome patterns could function as biomarkers for patient-tailored targeting of senescence in OA. Accumulation [...]
R Coutinho de Almeida, M Tuerlings, YFM Ramos, W den Hollander, HED Suchiman, N Lakenberg, RGHH Nelissen, H Mei, I Meulenbelt | 30-04-2022 | Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in OA. Abstract Objectives To present an unbiased approach to identify positional transcript single nucleotide polymorphisms (SNPs) [...]
WWP2 confers risk to OA by affecting cartilage matrix deposition via hypoxia associated genes| January 2023 | Osteoarthritis and Cartilage M Tuerlings, GMC Janssen, I Boone, M van Hoolwerff, A Rodriguez Ruiz, E Houtman, HED Suchiman, RJP van der Wal, RGHH Nelissen, R Coutinho de Almeida, PA van Veelen, YFM Ramos, I Meulenbelt Abstract [...]
