prof.dr. Ingrid Meulenbelt
Professor Molecular Biology of Osteoarthritis
Ingrid Meulenbelt is professor of the molecular biology of osteoarthritis and heads the Osteoarthritis research group within the Molecular Epidemiology section of the Department of Biomedical Data Sciences. She is vice chair of the LUMC VENI committee and member of the operational education consultation of the master biomedical sciences (OOO MaBMS). In 2016, Meulenbelt received an NWO-VICI grant to map the diversity of the underlying molecular osteoarthritis processes. Meulenbelt is a member of the organizing committee of the prestigious international osteoarthritis congress; OsteoArthritis Society International (OARSI) as chair of the abstract (2019) and the program (2020).
Molecular biology of osteoarthritis
Meulenbelt’s chair focuses on the molecular biology of osteoarthritis. Osteoarthritis is a debilitating joint disease that affects 1.2 million people in the Netherlands, but for which no effective medicine is yet available. Patients are therefore often dependent on physiotherapy and/or palliative care for many years, which causes a high social and economic burden of disease.
The starting point of Meulenbelt’s chair is that the development of effective treatment for osteoarthritis is seriously hindered because the disease process differs considerably between patients.
To unravel the diversity in the osteoarthritis process, Meulenbelt focuses first of all on mapping the characteristic differences at the molecular level between the disease processes that take place in bone and cartilage of patients undergoing joint replacement surgery for osteoarthritis. Based on these characteristic molecular patterns (genetics, transcription, and epigenetics) a human model system of osteoarthritis, an osteoarthritis joint-on-chip, is then developed. This allows further study of the biological basis of these different disease processes in bone and cartilage. By using stem cells (iPSCs) that are stimulated to make high-quality bone and cartilage, a reproducible model is created. With this methodology development, the research also contributes to regenerative medicine within the osteoarthritis field.
Risk factors of osteoarthritis in humans such as heredity and mechanical stress can then be applied in the model to initiate the osteoarthritis process. The model can also be used to search for new targets for effective tailor-made osteoarthritis therapy. To enable translation to the clinic, molecular signaling molecules are detected in blood that can report the disease process present in tissues. As such, the chair addresses several questions from the National Research Agenda and contributes to the important social challenge known as osteoarthritis.
Scientific career
Professor Ingrid Meulenbelt graduated cum laude from the University of Amsterdam in 1990 with a degree in Medical Biology. After working for 2 years as a researcher at Medscand Ingeny, she started her PhD research at Leiden University in 1992 entitled ‘Genetic risk factors of osteoarthritis’, which she completed in 1997. As a postdoc researcher at TNO Prevention and Health, she continued her osteoarthritis research and set up the landmark study Genetics Osteoarthritis and Progression (GARP) together with the Rheumatology department. In 2000, she transferred to the Leiden University Center (LUMC) as an assistant professor and started her own line of research in functional genomic osteoarthritis research. In 2008, now as an associate professor, she started a second landmark study called Research in Articular Arthrosis Cartilage (RAAK), this time with the Department of Orthopedics. The RAAK study still forms the foundation of current osteoarthritis research in Meulenbelt’s group. In 2016 she received a prestigious VICI grant from NWO and partly as a result of this she was appointed professor in the Molecular Biology of Osteoarthritis at the LUMC in 2017. Her inauguration took place on 19-01-2018 and was titled: ‘Arthrosis from diversity in molecular pathways to effective tailor-made therapy’.
Key grants and awards
NWO Vici (ronde 2015, toegekend in 2016)
ReumaNederland langlopende onderzoeksfinanciering (2023, 5 jaar)
NWO ENW-GROOT (2020, consortiumsubsidie)
H2020 (Europese Commissie) — AutoCRAT-consortium
Supervision scientific researchers and PhD students
2026
Dr Sana Sayedipour, thesis title: ‘Development of innovative therapeutic strategies for osteoarthritis: exploring thermosensitive hydrogels, hiPSC-derived cells and cell-products, and novel drugs in preclinical models’
2025
Dr Niek Bloks, thesis title: ‘Modeling the genetic and mechanical interplay in osteoarthritis: from in vitro systems to mechanistic insights‘
Dr Ilja Boone, thesis title: ‘Exploring senescent chondrocytes during aging: sleeper AGEnts of osteoarthritis’
2023
Dr Ritchie Timmermans, thesis title: ‘Application of 3D human in vitro osteoarthritic chondrocyte models to study CCN4/WISP1 and Wnt signaling’
Dr Margo Tuerlings, thesis title: ‘The bone and cartilage interplay in osteoarthritis: key to effective treatment strategy.’
2022
Dr Alejandro Rodriguez Ruiz, thesis title: ‘Osteoprotegerin: a double-edged sword in osteoarthritis development‘
Dr Evelyn Houtman, proefschrift titel: ‘Aged human osteochondral explants as biomimetic osteoarthritis model: towards a druggable target in osteoarthritis‘
Dr Marcella van Hoolwerff, thesis title: ‘Dissecting cellular function of fibronectin in osteoarthritic cartilage‘
2019
Dr Jennifer Meessen, thesis title: ‘Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling‘
2018
Dr Wouter den Hollander, thesis title: ‘On the relation between genetic variation and osteoarthritis‘
2017
Dr Nils Bömer, thesis title: ‘Thyroid hormone signalling in Osteoarthritis‘
2015
Dr Yolande Ramos, thesis title: ‘Osteoarthritis, a degenerative disease of the articular joints: towards the implementation of functional genomics in OA‘
2011
Dr Rita Slof-Op ‘t Landt, thesis title: ‘Genetic Determinants of Eating Disorders’
2010
Dr Steffan Bos, thesis title: ‘Genes and mediators of inflammation and development in osteoarthritis‘
2007
Dr Josine Min, thesis title: ‘Generalised osteoarthritis: from mendelian disorder to complex disease’
2006
Dr Naghmeh Riyazi, thesis title: ‘Familial osteoarthritis. Risk factors and determinants of outcome’