Professor P. Eline Slagboom obtained her master’s degree in biology in 1987 and her postgraduate degree in biochemistry in 1993. Between 1993 and 2000, Slagboom was a researcher at the Department of Vascular and Connective Tissue Research at the Gaubius Laboratory, TNO Prevention and Health (TNO-PG), the Netherlands. She started a genetic epidemiological research group that focused on identifying genetic determinants of multifactorial disorders. In 2000 she received an NWO program grant from the Netherlands Organization for Scientific Research (NWO) and she was appointed professor of Molecular Epidemiology at the Leiden University Medical Center (LUMC). She set up a new Molecular Epidemiology section (Molepi) and the genotyping center (staff now 30 FTE).
For the past 10 years, the focus of research has been to use omicsdata (genetic, transcriptomic, epigenetic, glycomic, metabolic data) in molecular epidemiological studies to find biomarkers of aging and age-related diseases in human cohorts and to explore the pathways behind these complex traits. For this purpose, a diversity of human cohorts with unique study designs are analyzed. Among these cohorts is the Dutch Hunger Winter Study cohort to investigate the late consequences of prenatal exposure under unfavorable conditions.
Slagboom is one of the co-founders of aging research within the LUMC, supported by various foundations through the Netherlands Genomics Initiative (NGI). She initiated both the Leiden Long Life Study (in collaboration with Professor RGJ Westendorp) and the osteoarthritis progression study (GARP: Genetics, Arthrosis and PRogression) study (in collaboration with Dr Ingrid Meulenbelt and Professor M. Kloppenburg) and is the principal investigator (PI) of these studies. Furthermore, Slagboom has started Molecular Epidemiology and Bioinformatics and she gives master classesin this field.
In addition, Slagboom is a member of many national reading committees, including the Netherlands Organization for Scientific Research (NWO) interdisciplinary VIDI committee (2007-2010), Netherlands Heart Foundation Scientific Advisory Committee (2007-2011) and she is an editorial board member of the scientific journal “Aging Cell ”. She has a leading role in large consortia in aging research such as the “Netherlands Consortium for Healthy Ageing” (NCHA) as scientific director in which she has set up a collaborative research with industry, and in the steering committee or as a member of large-scale EU joint research projects (Treat ~ OA, GEHA and LifeSpan) Eline Slagboom is PI of a new large-scale collaborative EU project that started in 2011 (IDEAL: Integrated research on DEvelopmental determinants of Ageing and Longevity) en van een “Biobanking and Biomolecular Research Infrastructure” (BBMRI) Regenboog project op Metabolomics.
download CV Eline Slagboom (in het engels)
Supervision of scientific researchers and PhD students
Dr Wouter den Hollander, dissertation title: ‘On the relation between genetic variation and osteoarthritis‘
Dr Jesse Krijthe, dissertation title: ‘Robust Semi-supervised Learning: Projections, Limits & Constraints‘
Dr Roderick Slieker, dissertation title: ‘Charting the dynamic methylome across the human lifespan‘
Dr Nils Bömer, dissertation title:’Thyroid hormone signalling in Osteoarthritis‘
Dr Jonathan K Vis, dissertation title: ‘Algorithms for the description of molecular sequences‘
Dr Yolande Ramos, dissertation title:: ‘Osteoarthritis, a degenerative disease of the articular joints: towards the implementation of functional genomics in OA‘
Dr Jenny van Dongen, dissertation title: ‘(Epi) genetics and twins‘ (cum laude).
Dr Erik van den Akker, dissertation title:: ‘Computational Biology in Human Aging – An Omics Data Integration Approach‘ in 2015
Dr Rudolf Talens, dissertation title:: ‘Studies into epigenetic variation and its contribution to cardiovascular disease‘ in 2015
Dr Joris Deelen, dissertation title:: ‘Genetic and biomarker studies of human longevity‘ (cum laude).
Dr Anika Vaarhorst, dissertation title:: ‘Genetic and Metabolomic approaches for Coronary Heart Disease risk prediction‘ in 2014
Dr Willemijn Passtoors, pdissertation title:: ‘Transcriptomic studies in human ageing and longevity‘
Dr Elmar Tobi, dissertation title:: ‘Epigenetic differences after prenatal adversity : the Dutch hunger winter‘
Dr Maarten Rozing, dissertation title:: ‘Endocrine and metabolic features of familial longevity The Leiden Longevity Study’
Dr Rita Slof-Op ‘t Landt, dissertation title: ‘Genetic Determinants of Eating Disorders’
Dr Renee Ruhaak, dissertation title:: ‘Glycomics based biomarkers of the rate of aging: development and applications of high-throughput N-glycan analysis‘
Dr Steffan Bos, dissertation title:: ‘Genes and mediators of inflammation and development in osteoarthritis‘
Dr Maris Kuningas,dissertation title:: ‘A Study into Genes Encoding Longevity in Humans’
Dr Josine Min, dissertation title:: ‘Generalised osteoarthritis: from mendelian disorder to complex disease’ in 2007.
Dr Naghmeh Riyazi, dissertation title:: ‘Familial osteoarthritis. Risk factors and determinants of outcome’ in 2006.
Dr Behrooz Alizadeh, dissertation title:: ’Osteoarthritis and hemochromatosis, a genetic epidemiological study’ in 2005.
Dr Marian Beekman, dissertation title:‘Towards mapping QTLs influencing parameters of Lipid Metabolism in Human Twins’ in 2004.
Dr Bas Heijmans, dissertation title: ‘Common Gene Variants and Mortality in the Population at Large’
Dr Casper Bijkerk, dissertation title: ‘Genetic epidemiology of osteoarthritis‘ in 1999.
Dr Ingrid Meulenbelt, dissertation title: ‘Genetic Predisposing Factors Of Osteoarthritis’ in 1997.