Papers Ageing
ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline
Swier Garst,[...], P Eline Slagboom, Joyce van Meurs | 18-05-2026 | Because individuals age at different rates, robust aging biomarkers are needed beyond chronological age. However, the methodological choices that shape such biomarkers have not been compared in a unified framework. This study addresses [...]
Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial
Bogaards FA, Groenendijk I, [...], Slagboom PE | 17-04-2026 | Nutritional weight-loss interventions are known to reduce bone mineral density (BMD), which can be prevented by adding (resistance) exercise training. However, this combined effect is not well studied in non-obese adults. In addition, the [...]
Healthful plant-based diet associates with greater well-being in older adults
A shift towards a more plant-based diet is promoted as healthy as well as sustainable. Whether this also applies to older adults is however less clear: On one hand plant-based diets may lead to energy deficits among vulnerable older adults and therefore negatively impact [...]
Functional Changes of T-Cell Subsets with Age and CMV Infection
Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, Solana R. | September 15th 2021 | Int J Mol Sci. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973. Abstract Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype [...]
Improved selection of participants in genetic longevity studies: family scores revisited
Improved selection of participants in genetic longevity studies: family scores revisited | BMC Medicine | January 2021 Rodriguez-Girondo, M.; Berg, N. van den; Hof, M.H.; Beekman, M.; Slagboom, E. Background: Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying [...]
Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape
Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape | Diebetes | October 2021 Sofia Thomaidou, Roderick C Slieker, Arno R van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M 't Hart, Bobby Koeleman, Françoise Carlotti, Rob C Hoeben, Bart O Roep, Hailiang Mei, Arnaud Zaldumbide Abstract Type 1 diabetes [...]