DECEMBER

Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HE, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, Freund C, Mummery C, Everts V, de Vries TJ, Ramos YFM, Meulenbelt I. Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization. Rheumatology (Oxford). 2022 Dec 23;62(1):360-372. doi: 10.1093/rheumatology/keac232.

Morwani-Mangnani J, Giannos P, Belzer C, Beekman M, Eline Slagboom P, Prokopidis K. Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia? Sleep. 2022 Dec 12;45(12):zsac239. doi: 10.1093/sleep/zsac239.

Houtman E, Tuerlings M, Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes. Rheumatology (Oxford). 2022 Dec 23;62(1):457-466. doi: 10.1093/rheumatology/keac202

NOVEMBER

Bogaards FA, Gehrmann T, Beekman M, van den Akker EB, van de Rest O, Hangelbroek RWJ, Noordam R, Mooijaart SP, de Groot LCPGM, Reinders MJT, Slagboom PE. PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults. FASEB J. 2022 Nov;36(11):e22578. doi: 10.1096/fj.202201037R

Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Bizzarri D, Vojinovic D, Upmeier Zu Belzen J, Loock L, Kittner P, Christmann L, Hollmann N, Strangalies H, Braunger JM, Wild B, Chiesa ST, Spranger J, Klostermann F, van den Akker EB, Trompet S, Mooijaart SP, Sattar N, Jukema JW, Lavrijssen B, Kavousi M, Ghanbari M, Ikram MA, Slagboom E, Kivimaki M, Langenberg C, Deanfield J, Eils R, Landmesser U. Metabolomic profiles predict individual multidisease outcomes. Nat Med. 2022 Nov;28(11):2309-2320. doi: 10.1038/s41591-022-01980-3.

SEPTEMBER

Ramos YFM, Tertel T, Shaw G, Staubach S, de Almeida RC, Suchiman E, Kuipers TB, Mei H, Barry F, Murphy M, Giebel B, Meulenbelt I. Characterizing the secretome of licensed hiPSC-derived MSCs. Stem Cell Res Ther. 2022 Sep 2;13(1):434. doi: 10.1186/s13287-022-03117-2

AUGUSTUS

Bizzarri D, Reinders MJT, Beekman M, Slagboom PE, van den Akker EB. MiMIR: R-shiny application to infer risk factors and endpoints from Nightingale Health’s 1H-NMR metabolomics data.Bioinformatics. 2022 Aug 2;38(15):3847-3849. doi: 10.1093/bioinformatics/btac388

Wiersema JM, Kamphuis AEP, Rohling JHT, Kervezee L, Akintola AA, Jansen SW, Slagboom PE, van Heemst D, van der Spoel E. The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging. Aging (Albany NY). 2022 Aug 16;14(18):7223-7239. doi: 10.18632/aging.204219.

Stokes CS, Weber D, Wagenpfeil S, Stuetz W, Moreno-Villanueva M, Dollé MET, Jansen E, Gonos ES, Bernhardt J, Grubeck-Loebenstein B, Fiegl S, Sikora E, Toussaint O, Debacq-Chainiaux F, Capri M, Hervonen A, Slagboom PE, Breusing N, Frank J, Bürkle A, Franceschi C, Grune T. Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort. Br J Nutr. 2022 Aug 14;128(3):433-443. doi: 10.1017/S0007114521004633.

JULI

Tuerlings M, van Hoolwerff M, van Bokkum JM, Suchiman HED, Lakenberg N, Broekhuis D, Nelissen RGHH, Ramos YFM, Mei H, Cats D, Coutinho de Almeida R, Meulenbelt I. Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis. Rheumatology (Oxford). 2022 Jul 6;61(7):3023-3032. doi: 10.1093/rheumatology/keab826

Kreitmaier P, Suderman M, Southam L, Coutinho de Almeida R, Hatzikotoulas K, Meulenbelt I, Steinberg J, Relton CL, Wilkinson JM, Zeggini E.  An epigenome-wide view of osteoarthritis in primary tissues. Am J Hum Genet. 2022 Jul 7;109(7):1255-1271. doi: 10.1016/j.ajhg.2022.05.010.

Niehues A, Bizzarri D, Reinders MJT, Slagboom PE, van Gool AJ, van den Akker EB; BBMRI-NL BIOS consortium; BBMRI-NL Metabolomics consortium; ’t Hoen PAC. Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies. BMC Genomics. 2022 Jul 31;23(1):546. doi: 10.1186/s12864-022-08771-7

JUNI

Katsoula G, Steinberg J, Tuerlings M, Coutinho de Almeida R, Southam L, Swift D, Meulenbelt I, Wilkinson JM, Zeggini E. A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis. Hum Mol Genet. 2022 Jun 22;31(12):2090-2105. doi: 10.1093/hmg/ddac017.

MEI

Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B, Walton E, Mishra PP, Schlosser P, Wilson R, Tsai PC, Palaniswamy S, Marioni RE, Fiorito G, Cugliari G, Karhunen V, Ghanbari M, Psaty BM, Loh M, Bis JC, Lehne B, Sotoodehnia N, Deary IJ, Chadeau-Hyam M, Brody JA, Cardona A, Selvin E, Smith AK, Miller AH, Torres MA, Marouli E, Gào X, van Meurs JBJ, Graf-Schindler J, Rathmann W, Koenig W, Peters A, Weninger W, Farlik M, Zhang T, Chen W, Xia Y, Teumer A, Nauck M, Grabe HJ, Doerr M, Lehtimäki T, Guan W, Milani L, Tanaka T, Fisher K, Waite LL, Kasela S, Vineis P, Verweij N, van der Harst P, Iacoviello L, Sacerdote C, Panico S, Krogh V, Tumino R, Tzala E, Matullo G, Hurme MA, Raitakari OT, Colicino E, Baccarelli AA, Kähönen M, Herzig KH, Li S; BIOS consortium; Conneely KN, Kooner JS, Köttgen A, Heijmans BT, Deloukas P, Relton C, Ong KK, Bell JT, Boerwinkle E, Elliott P, Brenner H, Beekman M, Levy D, Waldenberger M, Chambers JC, Dehghan A, Järvelin MR.  DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nat Commun. 2022 May 3;13(1):2408. doi: 10.1038/s41467-022-29792-6.

Monteagudo S, Cornelis FMF, Wang X, de Roover A, Peeters T, Quintiens J, Sermon A, de Almeida RC, Meulenbelt I, Lories RJ.  ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease. Osteoarthritis Cartilage. 2022 May;30(5):724-734. doi: 10.1016/j.joca.2022.02.615.

Buurstede JC, van Weert LTCM, Colucci P, Gentenaar M, Viho EMG, Koorneef LL, Schoonderwoerd RA, Lanooij SD, Moustakas I, Balog J, Mei H, Kielbasa SM, Campolongo P, Roozendaal B, Meijer OC.  Hippocampal glucocorticoid target genes associated with enhancement of memory consolidation. Eur J Neurosci. 2022 May;55(9-10):2666-2683. doi: 10.1111/ejn.15226.

APRIL

Rodríguez Ruiz A, van Hoolwerff M, Sprangers S, Suchiman HED, Schoenmaker T, Dibbets-Schneider P, Bloem JL, Nelissen RGHH, Freund C, Mummery C, Everts V, de Vries TJ, Ramos YFM, Meulenbelt I. Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization. Rheumatology (Oxford). 2022 Apr 12:keac232. doi: 10.1093/rheumatology/keac232.

Houtman E, Tuerlings M, D Suchiman HE, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes. Rheumatology (Oxford). 2022 Apr 5:keac202. doi: 10.1093/rheumatology/keac202.

MAART

van der Spek A, Karamujić-Čomić H, Pool R, Bot M, Beekman M, Garmaeva S, Arp PP, Henkelman S, Liu J, Alves AC, Willemsen G, van Grootheest G, Aubert G; BBMRI Metabolomics Consortium; Ikram MA, Jarvelin MR, Lansdorp P, Uitterlinden AG, Zhernakova A, Slagboom PE, Penninx BWJH, Boomsma DI, Amin N, van Duijn CM. Fat metabolism is associated with telomere length in six population-based studies. Hum Mol Genet. 2022 Mar 31;31(7):1159-1170. doi: 10.1093/hmg/ddab281

Albalak G, Stijntjes M, Wijsman CA, Slagboom PE, van der Ouderaa FJ, Mooijaart SP, van Heemst D, Noordam R. Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis. Int J Obes (Lond). 2022 Mar;46(3):515-522. doi: 10.1038/s41366-021-01018-7.

FEBRUARI

Rodríguez Ruiz A, Tuerlings M, Das A, Coutinho de Almeida R, Suchiman HED, Nelissen RGHH, Ramos YFM, Meulenbelt I. The role of TNFRSF11B in development of osteoarthritic cartilage. Rheumatology (Oxford). 2022 Feb 2;61(2):856-864. doi: 10.1093/rheumatology/keab440

JANUARI

Jonkman TH, Dekkers KF, Slieker RC, Grant CD, Ikram MA, van Greevenbroek MMJ, Franke L, Veldink JH, Boomsma DI, Slagboom PE, Consortium BIOS, Heijmans BT. Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression. Genome Biol. 2022 Jan 14;23(1):24. doi: 10.1186/s13059-021-02585-8

Hall M, van der Esch M, Hinman RS, Peat G, de Zwart A, Quicke JG, Runhaar J, Knoop J, van der Leeden M, de Rooij M, Meulenbelt I, Vliet Vlieland T, Lems WF, Holden MA, Foster NE, Bennell KL. How does hip osteoarthritis differ from knee osteoarthritis? Osteoarthritis Cartilage. 2022 Jan;30(1):32-41. doi: 10.1016/j.joca.2021.09.010.

Bizzarri D, Reinders MJT, Beekman M, Slagboom PE, BBMRI-NL, van den Akker EB. 1H-NMR metabolomics-based surrogates to impute common clinical risk factors and endpoints. EBioMedicine. 2022 Jan;75:103764. doi: 10.1016/j.ebiom.2021.103764.