PAPERS 2020

2020

DECEMBER

Beenakker KGM, Westendorp RGJ, de Craen AJM, Chen S, Raz Y, Ballieux BEPB, Nelissen RGHH, Later AFL, Huizinga TW, Slagboom PE, Boomsma DI, Maier AB. Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations. J Innate Immun. 2020;12(2):142-153.

Knol MJ, Lu D, Traylor M, Adams HHH, Romero JRJ, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, Trompet S, Giese AK, Hilal S, van den Akker EB, Vojinovic D, Li S, Sigurdsson S, van der Lee SJ, Jack CR Jr, Wilson D, Yilmaz P, Satizabal CL, Liewald DCM, van der Grond J, Chen C, Saba Y, van der Lugt A, Bastin ME, Windham BG, Cheng CY, Pirpamer L, Kantarci K, Himali JJ, Yang Q, Morris Z, Beiser AS, Tozer DJ, Vernooij MW, Amin N, Beekman M, Koh JY, Stott DJ, Houlden H, Schmidt R, Gottesman RF, MacKinnon AD, DeCarli C, Gudnason V, Deary IJ, van Duijn CM, Slagboom PE, Wong TY, Rost NS, Jukema JW, Mosley TH, Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS; Alzheimer’s Disease Neuroimaging Initiative. Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology. 2020 Dec 15;95(24):e3331-e3343. doi: 10.1212/WNL.0000000000010852

Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC, van der Grond J, Wright MJ, Knol MJ, Dörr M, Thomson RJ, Bordes C, Le Grand Q, Duperron MG, Smith AV, Knopman DS, Schreiner PJ, Evans DA, Rotter JI, Beiser AS, Maniega SM, Beekman M, Trollor J, Stott DJ, Vernooij MW, Wittfeld K, Niessen WJ, Soumaré A, Boerwinkle E, Sidney S, Turner ST, Davies G, Thalamuthu A, Völker U, van Buchem MA, Bryan RN, Dupuis J, Bastin ME, Ames D, Teumer A, Amouyel P, Kwok JB, Bülow R, Deary IJ, Schofield PR, Brodaty H, Jiang J, Tabara Y, Setoh K, Miyamoto S, Yoshida K, Nagata M, Kamatani Y, Matsuda F, Psaty BM, Bennett DA, De Jager PL, Mosley TH, Sachdev PS, Schmidt R, Warren HR, Evangelou E, Trégouët DA; International Network against Thrombosis (INVENT) Consortium; International Headache Genomics Consortium (IHGC), Ikram MA, Wen W, DeCarli C, Srikanth VK, Jukema JW, Slagboom EP, Kardia SLR, Okada Y, Mazoyer B, Wardlaw JM, Nyquist PA, Mather KA, Grabe HJ, Schmidt H, Van Duijn CM, Gudnason V, Longstreth WT Jr, Launer LJ, Lathrop M, Seshadri S, Tzourio C, Adams HH, Matthews PM, Fornage M, Debette S. Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun. 2020 Dec 8;11(1):6285. doi: 10.1038/s41467-020-19111-2.

NOVEMBER

van den Akker EB, Makrodimitris S, Hulsman M, Brugman MH, Nikolic T, Bradley T, Waisfisz Q, Baas F, Jakobs ME, de Jong D, Slagboom PE, Staal FJT, Reinders MJT, Holstege H. Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian. Leukemia. 2020 Nov 12. doi: 10.1038/s41375-020-01086-0.

van Hoolwerff M, Metselaar PI, Tuerlings M, Suchiman HED, Lakenberg N, Ramos YFM, Cats D, Nelissen RGHH, Broekhuis D, Mei H, de Almeida RC, Meulenbelt I. Elucidating Epigenetic Regulation by Identifying Functional cis-Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage. Arthritis Rheumatol. 2020 Nov;72(11):1845-1854. doi: 10.1002/art.41396.

OKTOBER

van den Akker EB, Trompet S, Barkey Wolf JJH, Beekman M, Suchiman HED, Deelen J, Asselbergs FW, Boersma E, Cats D, Elders PM, Geleijnse JM, Ikram MA, Kloppenburg M, Mei H, Meulenbelt I, Mooijaart SP, Nelissen RGHH, Netea MG, Penninx BWJH, Slofstra M, Stehouwer CDA, Swertz MA, Teunissen CE, Terwindt GM, ‘t Hart LM, van den Maagdenberg AMJM, van der Harst P, van der Horst ICC, van der Kallen CJH, van Greevenbroek MMJ, van Spil WE, Wijmenga C, Zhernakova A, Zwinderman AH, Sattar N, Jukema JW, van Duijn CM, Boomsma DI, Reinders MJT, Slagboom PE. Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circ Genom Precis Med. 2020 Oct;13(5):541-547. doi: 10.1161/CIRCGEN.119.002610.

Boer CG, Yau MS, Rice SJ, Coutinho de Almeida R, Cheung K, Styrkarsdottir U, Southam L, Broer L, Wilkinson JM, Uitterlinden AG, Zeggini E, Felson D, Loughlin J, Young M, Capellini TD, Meulenbelt I, van Meurs JB. Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene. Ann Rheum Dis. 2020 Oct 14;80(3):367-75. doi: 10.1136/annrheumdis-2020-217834.

van der Graaf A, Claringbould A, Rimbert A; BIOS Consortium, Westra HJ, Li Y, Wijmenga C, Sanna S. Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids. Nat Commun. 2020 Oct 1;11(1):4930. doi: 10.1038/s41467-020-18716-x.

van der Sijp MPL, Suchiman HED, Eijk M, Vojinovic D, Niggebrugge AHP, Blauw GJ, Achterberg WP, Slagboom PE. The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture. Geriatr Orthop Surg Rehabil. 2020 Oct 29;11:2151459320960091. doi: 10.1177/2151459320960091.

SEPTEMBER

Hammerschlag AR, Byrne EM; eQTLGen Consortium; BIOS Consortium, Bartels M, Wray NR, Middeldorp CM. Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies. Biol Psychiatry. 2020 Sep 15;88(6):470-479. doi: 10.1016/j.biopsych.2020.05.002.

Meessen JMTA, Saberi-Hosnijeh F, Bomer N, den Hollander W, van der Bom JG, van Hilten JA, van Spil WE, So-Osman C, Uitterlinden AG, Kloppenburg M, Nelissen RGHH, van Duijn CM, Slagboom PE, van Meurs JBJ, Meulenbelt I. Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI. Sci Rep. 2020 Sep 22;10(1):15459. doi: 10.1038/s41598-020-71811-3

Ross AK, Coutinho de Almeida R, Ramos YFM, Li J, Meulenbelt I, Guilak F. The miRNA-mRNA interactome of murine induced pluripotent stem cell-derived chondrocytes in response to inflammatory cytokines. FASEB J. 2020 Sep;34(9):11546-11561. doi: 10.1096/fj.202000889R.

Verheul MK, Janssen GMC, de Ru A, Stoeken-Rijsbergen G, Levarht EWN, Kwekkeboom JC, Bomer N, Ioan-Facsinay A, Meulenbelt I, Cordfunke RA, Drijfhout JW, Toes REM, van Veelen PA, Trouw LA. Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls. Clin Exp Rheumatol. 2020 Sep 1. Online ahead of print

AUGUSTUS

Hop PJ, Luijk R, Daxinger L, van Iterson M, Dekkers KF, Jansen R; BIOS Consortium, van Meurs JBJ, ‘t Hoen PAC, Ikram MA, van Greevenbroek MMJ, Boomsma DI, Slagboom PE, Veldink JH, van Zwet EW, Heijmans BT. Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference. Genome Biol. 2020 Aug 28;21(1):220. doi: 10.1186/s13059-020-02114-z

JULI

Benedetti E, Gerstner N, Pučić-Baković M, Keser T, Reiding KR, Ruhaak LR, Štambuk T, Selman MHJ, Rudan I, Polašek O, Hayward C, Beekman M, Slagboom E, Wuhrer M, Dunlop MG, Lauc G, Krumsiek J. Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference. Metabolites. 2020 Jul 2;10(7):271. doi: 10.3390/metabo10070271.

JUNI

van den Berg N, Rodríguez-Girondo M, Mandemakers K, Janssens AAPO, Beekman M, Slagboom PE. Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies. Aging Cell. 2020 Jun;19(6):e13139. doi: 10.1111/acel.13139.

Pool R, Hagenbeek FA, Hendriks AM, van Dongen J, Willemsen G, de Geus E; BBMRI Metabolomics Consortium, Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, Harms AC, Hankemeier T, Boomsma DI. Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data. Twin Res Hum Genet. 2020 Jun;23(3):145-155. doi: 10.1017/thg.2020.53.

Spitali P, Zaharieva I, Bohringer S, Hiller M, Chaouch A, Roos A, Scotton C, Claustres M, Bello L, McDonald CM, Hoffman EP; CINRG Investigators, Koeks Z, Eka Suchiman H, Cirak S, Scoto M, Reza M, ‘t Hoen PAC, Niks EH, Tuffery-Giraud S, Lochmüller H, Ferlini A, Muntoni F, Aartsma-Rus A. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy. Eur J Hum Genet. 2020 Jun;28(6):815-825. doi: 10.1038/s41431-019-0563-6.

 

 

MEI

Bryois J, Skene NG, Hansen TF, Kogelman LJA, Watson HJ, Liu Z; Eating Disorders Working Group of the Psychiatric Genomics Consortium; International Headache Genetics Consortium; 23andMe Research Team, Brueggeman L, Breen G, Bulik CM, Arenas E, Hjerling-Leffler J, Sullivan PF. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nat Genet. 2020 May;52(5):482-493. doi: 10.1038/s41588-020-0610-9.

Beekman M, Schutte BAM, Akker EBVD, Noordam R, Dibbets-Schneider P, de Geus-Oei LF, Deelen J, Rest OV, Heemst DV, Feskens EJM, Slagboom PE. Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter. Mol Nutr Food Res. 2020 May;64(10):e1900818. doi: 10.1002/mnfr.201900818.

APRIL

Raz Y, van den Akker EB, Roest T, Riaz M, van de Rest O, Suchiman HED, Lakenberg N, Stassen SA, van Putten M, Feskens EJM, Reinders MJT, Goeman J, Beekman M, Raz V, Slagboom PE. A data-driven methodology reveals novel myofiber clusters in older human muscles. FASEB J. 2020 Apr;34(4):5525-5537. doi: 10.1096/fj.201902350R.

van der Spoel E, Roelfsema F, Akintola AA, Jansen SW, Slagboom PE, Westendorp RGJ, Blauw GJ, Pijl H, van Heemst D. Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects. J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1201-14. doi: 10.1210/clinem/dgz253

MAART

Bos MM, Noordam R, Bennett K, Beekman M, Mook-Kanamori DO, Willems van Dijk K, Slagboom PE, Lundstedt T, Surowiec I, van Heemst D. Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity. Metabolomics. 2020 Mar 2;16(3):35. doi: 10.1007/s11306-020-01653-7.

Tilburg J, Slieker RC, Suchiman HED, Heath A, Heemst DV, Slagboom PE, de Gruijl FR, Gunn DA, Heijmans BT. Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response. Epigenomics. 2020 Apr;12(7):563-573. doi: 10.2217/epi-2019-0251.

Bot M, Milaneschi Y, Al-Shehri T, Amin N, Garmaeva S, Onderwater GLJ, Pool R, Thesing CS, Vijfhuizen LS, Vogelzangs N, Arts ICW, Demirkan A, van Duijn C, van Greevenbroek M, van der Kallen CJH, Köhler S, Ligthart L, van den Maagdenberg AMJM, Mook-Kanamori DO, de Mutsert R, Tiemeier H, Schram MT, Stehouwer CDA, Terwindt GM, Willems van Dijk K, Fu J, Zhernakova A, Beekman M, Slagboom PE, Boomsma DI, Penninx BWJH; BBMRI-NL Metabolomics Consortium. Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls. Biol Psychiatry. 2020 Mar 1;87(5):409-418. doi: 10.1016/j.biopsych.2019.08.016.

Hagenbeek FA, Pool R, van Dongen J, Draisma HM, Jan Hottenga J, Willemsen G, Abdellaoui A, Fedko IO, den Braber A, Visser PJ, de Geus EJCN, Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, van Duijn CM; BBMRI Metabolomics Consortium, Harms AC, Hankemeier T, Bartels M, Nivard MG, Boomsma DI. Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nat Commun. 2020 Mar 31;11(1):1702. doi: 10.1038/s41467-020-15276-y.

Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, Arp PP, Broer L, Buxton JL, Da Silva Couto Alves A, Deelen J, Fedko IO, Gordon SD, Jiang T, Karlsson R, Kerrison N, Loe TK, Mangino M, Milaneschi Y, Miraglio B, Pervjakova N, Russo A, Surakka I, van der Spek A, Verhoeven JE, Amin N, Beekman M, Blakemore AI, Canzian F, Hamby SE, Hottenga JJ, Jones PD, Jousilahti P, Mägi R, Medland SE, Montgomery GW, Nyholt DR, Perola M, Pietiläinen KH, Salomaa V, Sillanpää E, Suchiman HE, van Heemst D, Willemsen G, Agudo A, Boeing H, Boomsma DI, Chirlaque MD, Fagherazzi G, Ferrari P, Franks P, Gieger C, Eriksson JG, Gunter M, Hägg S, Hovatta I, Imaz L, Kaprio J, Kaaks R, Key T, Krogh V, Martin NG, Melander O, Metspalu A, Moreno C, Onland-Moret NC, Nilsson P, Ong KK, Overvad K, Palli D, Panico S, Pedersen NL, Penninx BWJH, Quirós JR, Jarvelin MR, Rodríguez-Barranco M, Scott RA, Severi G, Slagboom PE, Spector TD, Tjonneland A, Trichopoulou A, Tumino R, Uitterlinden AG, van der Schouw YT, van Duijn CM, Weiderpass E, Denchi EL, Matullo G, Butterworth AS, Danesh J, Samani NJ, Wareham NJ, Nelson CP, Langenberg C, Codd V. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020 Mar 5;106(3):389-404. doi: 10.1016/j.ajhg.2020.02.006.

Mulder RH, Neumann A, Cecil CAM, Walton E, Houtepen LC, Simpkin AJ, Rijlaarsdam J, Heijmans BT, Gaunt TR, Felix JF, Jaddoe VWV, Bakermans-Kranenburg MJ, Tiemeier H, Relton CL, van IJzendoorn MH, Suderman M. Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence. Hum Mol Genet. 2021 Mar 25;30(1):119-134. doi: 10.1093/hmg/ddaa280.

Salgado C, Gruis N; BIOS Consortium, Heijmans BT, Oosting J, van Doorn R. Genome-wide analysis of constitutional DNA methylation in familial melanoma. Clin Epigenetics. 2020 Mar 6;12(1):43. doi: 10.1186/s13148-020-00831-7

FEBRUARI

Klarić L, Tsepilov YA, Stanton CM, Mangino M, Sikka TT, Esko T, Pakhomov E, Salo P, Deelen J, McGurnaghan SJ, Keser T, Vučković F, Ugrina I, Krištić J, Gudelj I, Štambuk J, Plomp R, Pučić-Baković M, Pavić T, Vilaj M, Trbojević-Akmačić I, Drake C, Dobrinić P, Mlinarec J, Jelušić B, Richmond A, Timofeeva M, Grishchenko AK, Dmitrieva J, Bermingham ML, Sharapov SZ, Farrington SM, Theodoratou E, Uh HW, Beekman M, Slagboom EP, Louis E, Georges M, Wuhrer M, Colhoun HM, Dunlop MG, Perola M, Fischer K, Polasek O, Campbell H, Rudan I, Wilson JF, Zoldoš V, Vitart V, Spector T, Aulchenko YS, Lauc G, Hayward C. Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Sci Adv. 2020 Feb 19;6(8):eaax0301. doi: 10.1126/sciadv.aax0301.

Ouwens KG, Jansen R, Nivard MG, van Dongen J, Frieser MJ, Hottenga JJ, Arindrarto W, Claringbould A, van Iterson M, Mei H, Franke L, Heijmans BT, A C ‘t Hoen P, van Meurs J, Brooks AI; BIOS Consortium, Penninx BWJH, Boomsma DI. A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. Eur J Hum Genet. 2020 Feb;28(2):253-263. doi: 10.1038/s41431-019-0511-5.

JANUARI

Liu J, Lahousse L, Nivard MG, Bot M, Chen L, van Klinken JB, Thesing CS, Beekman M, van den Akker EB, Slieker RC, Waterham E, van der Kallen CJH, de Boer I, Li-Gao R, Vojinovic D, Amin N, Radjabzadeh D, Kraaij R, Alferink LJM, Murad SD, Uitterlinden AG, Willemsen G, Pool R, Milaneschi Y, van Heemst D, Suchiman HED, Rutters F, Elders PJM, Beulens JWJ, van der Heijden AAWA, van Greevenbroek MMJ, Arts ICW, Onderwater GLJ, van den Maagdenberg AMJM, Mook-Kanamori DO, Hankemeier T, Terwindt GM, Stehouwer CDA, Geleijnse JM, ‘t Hart LM, Slagboom PE, van Dijk KW, Zhernakova A, Fu J, Penninx BWJH, Boomsma DI, Demirkan A, Stricker BHC, van Duijn CM. Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas. Nat Med. 2020 Jan;26(1):110-117. doi: 10.1038/s41591-019-0722-x.

van der Poort EKJ, Gunn DA, Beekman M, Griffiths CEM, Slagboom PE, van Heemst D, Noordam R. Basal cell carcinoma genetic susceptibility increases the rate of skin ageing: a Mendelian randomization study. J Eur Acad Dermatol Venereol. 2020 Jan;34(1):97-100. doi: 10.1111/jdv.15880.

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